Holistic prediction of enantioselectivity in asymmetric catalysis
نویسندگان
چکیده
منابع مشابه
Reagent-controlled enantioselectivity switch for the asymmetric fluorination of β-ketocarbonyls by chiral primary amine catalysis.
A reagent-controlled enantioselectivity switch was uncovered in the asymmetric α-fluorination of β-ketocarbonyls by a chiral primary amine catalyst. By a simple swap of fluorination reagents, both enantiomers of the quaternary fluorination adducts could be obtained with good yields and high enantioselectivity. Mechanistic studies disclosed dual H-bonding and electrostatic stereocontrolling mode...
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...................................................................................................1 ACKNOWLEDGEMENTS...................................................................................2 TABLE OF CONTENTS.....................................................................................4 LIST OF COMMON ABBREVIATIONS.................................................................5
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ژورنال
عنوان ژورنال: Nature
سال: 2019
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-019-1384-z